Target Identification
The targets of antibodies obtained by phenotypical approaches are often unknown. MAbSilico identifies them.
MAbTarget
Lead Identification
MAbSilico finds few antibody candidates binding your target in large pools of molecules (from immune repertoires, antibody banks or other biobank).
MAbBinning
Lead Characterization
MAbSilico provides AI-based tools to identify the epitope and putative off-targets of an antibody. These characterizations can be done as soon as the sequence of the antibody is known and can be essential in the lead selection process.
MAbTope
MAbCross
Lead Optimization
You need to change your antibody framework? MAbSilico humanizes the sequence, optimizes its affinity for the target, improves cross-species binding and modifies the specificity.
MAbHuman
Antibody discovery
From MAbSilico antibody database of 70 million of sequence, MAbSilico finds alternative sequences to replace any antibody by computational antibody designed.
MAbSubstitute
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Identification of the target of an antibody. Only the sequences of the variable parts of the antibody are needed. Data on the binding of the antibody to different cell types can be used to refine the prediction.
Deliverable: list of up to 10 proteins per antibody
Price: per antibody
Prediction of the overlap of epitopes of a collection of antibodies, and prediction of the epitopes of antibodies. 3D structure of the target (or a close homolog) is needed.
Deliverable: list of group of antibodies with epitope disclosure for 3 groups
Price: per batch of 100 antibodies against 1 target
Epitope mapping of an antibody on its target. The sequence of the antibody and the structure of the traget are needed. If the structure is not solved, a preliminary study will be performed to evaluate if a model can be made.
Deliverable: epitope, paratope and 3D models
Price: per antibody
off-target identification from MAbSilico database (3,000 human proteins and 400,000 antibodies). Only the sequence of the antibody is required.
Deliverable: list of up to 10 proteins per antibody
Price: per antibody
Identification of human frameworks for CDR grafting (58 million human sequences in our database). Only the sequence of the antibody is required.
Deliverable: 5 antibody sequences
Price: per antibody
Clustering of antibodies based on similarity. Within one cluster, the antibodies bind the same epitope. Allows to deal with large numbers of antibodies, the 3D structure of the target is not necessary.
Deliverable: list of groups of antibodies binding the same epitope in 10 days
Price: per batch of 100 antibodies against 1 target
Prediction of the affinity of an antibody for its target
Deliverable: affinity data in 10 days
Price: per antibody
Identification of the best leads from large antibody batches (immune repertoire, naïve banks, etc) based on their affinity for the target and their pariwise similarity
Deliverable: sequences of the best leads and predicted affinity in 10 days
Price: per project
Maturation of the affinity of an antibody for its target
Deliverable: proposed mutations and predicted affinity in 10 days
Price: per antibody
Maturation of the specificity of an antibody. Allows to increase or decrease the affinity for several targets at the same time, for example orthologs and/or paralogs of initial target
Deliverable: proposed mutations and predicted affinity for each target in 10 days
Price: per antibody
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