We provide a software solutions to:

Target Identification

The targets of antibodies obtained by phenotypical approaches are often unknown. MAbSilico identifies them.

MAbTarget

On demand

Lead Identification

MAbSilico finds few antibody candidates binding your target in large pools of molecules (from immune repertoires, antibody banks or other biobank).

MAbBinning

Starting at 15 000 €

Lead Characterization

MAbSilico provides AI-based tools to identify the epitope and putative off-targets of an antibody. These characterizations can be done as soon as the sequence of the antibody is known and can be essential in the lead selection process.

MAbTope

MAbCross

Starting at 5 000 €

Lead Optimization

You need to change your antibody framework? MAbSilico humanizes the sequence, optimizes its affinity for the target, improves cross-species binding and modifies the specificity.

MAbHuman

Starting at 20 000 €

Antibody discovery

From MAbSilico antibody database of 70 million of sequence, MAbSilico finds alternative sequences to replace any antibody by computational antibody designed.

MAbSubstitute

On demand

Focus on the features:

MAbTarget

Identification of the target of an antibody. Only the sequences of the variable parts of the antibody are needed. Data on the binding of the antibody to different cell types can be used to refine the prediction.

Deliverable: list of up to 10 proteins per antibody

Price: per antibody

MAbBinning

Prediction of the overlap of epitopes of a collection of antibodies, and prediction of the epitopes of antibodies. 3D structure of the target (or a close homolog) is needed.

Deliverable: list of group of antibodies with epitope disclosure for 3 groups

Price: per batch of 100 antibodies against 1 target

MAbTope

Epitope mapping of an antibody on its target. The sequence of the antibody and the structure of the traget are needed. If the structure is not solved, a preliminary study will be performed to evaluate if a model can be made.

Deliverable: epitope, paratope and 3D models

Price: per antibody

MAbCross

off-target identification from MAbSilico database (3,000 human proteins and 400,000 antibodies). Only the sequence of the antibody is required.

Deliverable: list of up to 10 proteins per antibody

Price: per antibody

MAbHuman

Identification of human frameworks for CDR grafting (58 million human sequences in our database). Only the sequence of the antibody is required.

Deliverable: 5 antibody sequences

Price: per antibody

MAbSubstitute

Clustering of antibodies based on similarity. Within one cluster, the antibodies bind the same epitope. Allows to deal with large numbers of antibodies, the 3D structure of the target is not necessary.

Deliverable: list of groups of antibodies binding the same epitope in 10 days

Price: per batch of 100 antibodies against 1 target

New features coming soon

MAbAffinity

Prediction of the affinity of an antibody for its target

Deliverable: affinity data in 10 days

Price: per antibody

MAbSelect

Identification of the best leads from large antibody batches (immune repertoire, naïve banks, etc) based on their affinity for the target and their pariwise similarity

Deliverable: sequences of the best leads and predicted affinity in 10 days

Price: per project

MAbMaturity

Maturation of the affinity of an antibody for its target

Deliverable: proposed mutations and predicted affinity in 10 days

Price: per antibody

MAbSpecificity

Maturation of the specificity of an antibody. Allows to increase or decrease the affinity for several targets at the same time, for example orthologs and/or paralogs of initial target

Deliverable: proposed mutations and predicted affinity for each target in 10 days

Price: per antibody

Contact us

MAbSilico SAS

Le HQ

1 impasse du Palais 37000 Tours

FRANCE

contact@mabsilico.com